nosebleed caused by a pair of mackies? No. Headache / tinnitus, well quite possibly.
i think we all need to remember, sound is a very subjective thing, and as everybody has different tastes and hearing, we all like the sound of different systems.
The only piece of advice that i would offer here is:
Listen to your intended purchase, and if they sound good to you, tick all the practical and financial boxes, then go with them.
Dont buy of hearsay, you most likely wont find the right product.
Now, if you do want a nosebleed, let me plug in my 30kw Void acoustics Arcline system...